The .50 AE (Action Express) caliber with the metric dimensions of 12.7 x 36.6 is the strongest cartridge for semi-automatic pistols on the market. The most well-known weapon that is standardly delivered in .50 AE is the Desert Eagle.
With the Desert Eagle, 300 grain heavy projectiles are fired as standard, which have a muzzle energy of 400 m/s and an energy output of 1700 Joules. In comparison, conventional cartridges in 9 x 19 have a muzzle energy of about 360–750 Joules depending on the load. The image shows cartridges in different calibers for comparison. From left to right: (9x19, .357 SIG, .38 Special, .40 S&W, .45 ACP, .44 Magnum, .50 AE)
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